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Cutting-edge Molecular Tools Reveal Potential COVID-19 Diagnostic and Therapeutic Targets

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Using some of the most advanced molecular sequencing tools available to evaluate COVID-19 rapid autopsy tissues, researchers have identified four major regulatory pathways, specific molecular effectors behind COVID-19 symptoms, and differences that drive diverging clinical courses among individual patients. This research may pave the way for a more personalized and effective approach to COVID-19 diagnosis and treatment, researchers explain in a new study published in The American Journal of Pathology.

Original Post: medicalxpress.com

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Research Shows Why Immune Checkpoint Blockade Impedes but Does Not Stop Glioblastoma Progression

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Like locking the door but opening windows, an immune checkpoint therapy temporarily slows glioblastoma (GBM) progression but fails to establish an effective anti-tumor microenvironment and appears to increase molecular interactions inhibiting long-term immune response, according to studies led by a UCLA research team.

Original Post: medicalxpress.com

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Cancer Cells May Promote Metastases and Resistance to Therapy, Depending on Their State

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A type of cell transformation known as EMT enables cancer cells to break away from the tumor and form metastases elsewhere. However, this process does not always take place in full. Researchers at the University of Basel have now been able to show that tumor cells contribute differently to the formation of metastases and the development of therapy resistance, depending on whether they have undergone full or only partial transformation.

Article: medicalxpress.com

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Smart Wound Dressing Provides Suture-free Closure of Surgical Incisions

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“Sutures? That’s practically medieval!”

Original Article: medicalxpress.com

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