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Optimized Second-generation MRNA Vaccine Demonstrates Improved Protection Against COVID-19

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In a recent phase 2b/3 clinical trial, a third mRNA vaccine against COVID-19—known as CVnCoV and developed by CureVac—reported approximately 48 percent efficacy against symptomatic disease. CV2CoV is a second generation vaccine developed by CureVac with noncoding modifications to optimize the vaccine. Researchers at Beth Israel Deaconess Medical Center (BIDMC) conducted a head-to-head test of the second-generation vaccine CV2CoV compared with CVnCoV. The scientists assessed the vaccines’ ability to provoke an immune response as well as their protective efficacy against COVID-19 in non-human primates. Their findings are published in Nature.

Original Source: medicalxpress.com

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Research Shows Why Immune Checkpoint Blockade Impedes but Does Not Stop Glioblastoma Progression

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Like locking the door but opening windows, an immune checkpoint therapy temporarily slows glioblastoma (GBM) progression but fails to establish an effective anti-tumor microenvironment and appears to increase molecular interactions inhibiting long-term immune response, according to studies led by a UCLA research team.

Original Post: medicalxpress.com

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Cancer Cells May Promote Metastases and Resistance to Therapy, Depending on Their State

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A type of cell transformation known as EMT enables cancer cells to break away from the tumor and form metastases elsewhere. However, this process does not always take place in full. Researchers at the University of Basel have now been able to show that tumor cells contribute differently to the formation of metastases and the development of therapy resistance, depending on whether they have undergone full or only partial transformation.

Article: medicalxpress.com

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Smart Wound Dressing Provides Suture-free Closure of Surgical Incisions

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“Sutures? That’s practically medieval!”

Original Article: medicalxpress.com

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